Multiple research studies have linked gluten to the condition known as intestinal permeability – AKA – Leaky Gut Syndrome.  I recently had the privilege of speaking with one of the leading gluten sensitivity researchers in the world, Dr. Alessio Fasano.  He is the head of research at the University of Maryland Celiac Research Center, and he is responsible for discovering the gluten/leaky gut connection.  In this video, we discuss how this condition can affect the gut, the brain, and multiple other tissues in the body…

Making the Connection – The Gluten Free Warrior’s Stance:

Most people assume that celiac disease and gluten sensitivity are the same thing. Fortunately, this archaic thought is rapidly changing. Although it is well established that gluten often impacts the villi of the small intestine, it has also been shown to affect the body in multiple  ways. These differences account for the massive failure of doctors to diagnose gluten sensitivity. Below is a diagram of environmental triggers to intestinal permeability (leaky gut). You will find that gluten sensitivity can directly and indirectly contribute to this problem. To the intelligent observer, this picture illustrates why simple antibody testing fails to accurately diagnosis gluten sensitivity.  Antibody production is only one lab component of a multi-faceted problem.

Click on image to enlarge…

How Does Gluten Play a Role in All of These Factors?

  1. Gluten – Gluten directly impacts the intestinal lining through zonulin production. Zonulin is a protein that directly causes leaky gut.
  2. Antibodies – Gluten contributes to the formation antibodies. Antibodies can cause the secretion of inflammatory chemicals leading to tissue damage. Additionally, through a process called molecular mimicry, antibodies can cross react with the tissues of the body causing autoimmune disease. Lab tests measuring these antibodies are typically not associated with gluten because most doctors are not trained adequately to identify the connection.
  3. Medications – Many medications commonly contain gluten leading to a direct effect. However, many chronic health conditions caused by gluten sensitivity are misdiagnosed leading to medicine prescriptions that are not only unnecessary, but can be detrimental to the gastrointestinal tract. Anti-acid medications are a common example. These medications predispose to infection and lead to abnormal bacteria presence in the gut. Over utilization of antibiotics to treat viral infection is another example.
  4. Stress – Although not a physical stressor, gluten is a chemical stressor on the body. Chemical stress comes in many forms. One of them is vitamin and mineral deficiency. Loss of key nutrients causes a fundamental breakdown in the body’s ability to modulate the healing and repair process.
  5. Bacteria – Gluten ingestion causes detrimental changes in intestinal flora (AKA gut dysbiosis) predisposing to infection. This is one of the reasons why so many yogurt companies are adding beneficial bacteria to their products. Gut dysbiosis is an epidemic in the U.S.  If you need a gluten free probiotic go here <<<
  6. Cytokines – Gluten induces the production of pro-inflammatory cytokines (chemicals that damage cells).
  7. Neurotransmitters – Gluten causes neurochemical changes in the production of neurotransmitters (chemicals that allow the nervous system to communicate). Examples include: serotonin, dopamine, acetylcholine, epinephrine, and histamine. Gluten is also a neurotoxin that has been shown to damage nerve tissue. This is the reason so many with neurological disease (autism, ADD, bipolar, schizophrenia, neuropathy, epilepsy, etc.) do well on a gluten free diet.
  8. Digestive chemicals – Gluten can damage the intestine, the pancreas, the liver, and the gall bladder. All of these organs play a pivotal role in the body’s ability to produce digestive chemicals and enzymes. When this mechanism is compromised, digestive processes start to break down and become ineffective.

Restoring Leaky Gut

Restoration of intestinal permeability is not difficult.   In my experience there are some critical components that need to be addressed.

  1. Remove gluten from the diet
  2. Investigate for food allergies beyond gluten
  3. Identify and correct nutritional deficiencies
  4. Restore healthy bacteria in the gut (take a high potency probiotic)
  5. Provide immune factors that and natural anti-inflammatories to aid in the healing process
  6. Consider the use of a good digestive enzyme

Sum it all up –

Leaky gut contributes to autoimmune disease. The only known cause for any autoimmune disease is gluten sensitivity. We are blind fools to ignore this connection because it does not fit the status quo of the allopathic medical paradigm. If you have autoimmune disease and have not investigated gluten sensitivity as a contributing factor, you should. Learn more about genetic testing for gluten sensitivity now!

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Gluten Free Warrior Commentary


14 responses on “Dr. Fasano on Leaky Gut Syndrome and Gluten Sensitivity

  1. Maura Hoagland says:

    I have a ten year old daughter who has leaky gut syndrome. She is now on a gluten free diet, pharmaceutical grade pro-biotics, a homeopathic yeast cleanse (she tested positive for Candida as well), and digestive enzymes.

    My question is, is Leaky Gut Syndrome a life-long problem, or can she be healed from this?

  2. Sue says:

    My 8 year old daughter has had vitiligo for the past two years. We did some basic blood test which did not point to anything definitive. Right from when I stopped nursing her when she was about 18 months old, she has had digestive problems like severe constipation, tummy aches and general malaise. And then suddenly 2 years ago she started depigmenting. I started her on a gluten free diet (very challenging!) and her general health has improved, but there is no improvement in her skin condition. I wish gluten was the answer to her problem.


  3. Amanda says:

    Hi Sue, I had vitiligo all my life, I’m 51 on a gluten free diet, added coconut oil and I’m repigmenting! I only take 1 teaspoon daily, the reason I started taking virgin coconut oil was to loose weight. It does not hurt trying…

  4. Olik says:

    Dear Dr,
    I write from Poland. I had suddenly problem with health after I finished my studies. (But even when I felt so sick- devastated- and went to hospital I had good blood test.) In clinic I have biopsy -flattened intestinal villi IIIc Marshal… since that time ( 10 months) I;m on diet. However I sometimes feel tired, and I have muscle pain( all arm), and I can’t eat – after B vitamin injection I feel excellent and don’t have diarrhea and stomach pain. What’s more I have Hashimoto( take euthyrox). How can I know that I have leaky gut syndrome or celiac?

  5. Olik says:

    I’m 25/ weight 43 kg/ 176 height

  6. Alan says:

    Great article. Here is the latest publication from Fasano that takes the argument one step further.


  7. […] -There are 3 things that must be present in the body for the development of an auto-immune disorder. 1-Genetic vulnerability (a weak link in the chain); 2-Environmental triggers (a loss of tolerance to certain foods or toxins- the worst offender is gluten); 3-Intestinal permeability (a leaky gut – discovered by Dr. Alessio Fasano). […]

  8. Dee says:

    my 16 yr old son was recently diagnosed with Celiac Disease after 2 yrs of stomach and joint pain. He has been gluten free for 10 weeks and dairy free for over 4 months .2 weeks of GF he was feeling great and then his symptoms came back so we removed all grains. i am assuming this is due to leaky gut syndrome and he is having a cross reaction to certain foods. unfortunately not all doctors believe in leaky gut syndrome and when i say i learned it from the internet i am not being taken seriously. im on my own, other than books and the internet to try and get my son well again. im hoping after keeping my son off of all grains and dairy for a while his gut will heal and he will be able to eat gluten free grains.

  9. nima says:

    I am from Asia. please help me. I have 4 years old daughter that her wight is 12 kilo and her length is 94. so i thought she is ill after some blood test is shown that her Igg (ttg) was 763. and her genetic test showed (HLA DQ2 allel not identified – HLA DQ8 allele identified). please help me and guide me if she has celiac disease or gluten sensitivity
    best regard

    • Nima,
      for direct advice, please call my office and set up a consultation with me. To properly evaluate your daughter’s test results, I would need more information.
      All the best,
      Dr. Osborne

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Disclaimer: The entire contents of this website are based upon the opinions of Dr. Peter Osborne, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Osborne and his community. Dr. Osborne encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.

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