Flaws of Laboratory Testing to Identify Gluten IssuesIt is no mystery that serum (blood) tests to identify gluten sensitivity are fundamentally flawed. It is also no mystery that the intestinal biopsy is flawed as well. Unfortunately, doctors continue to use these tools definitively to diagnose celiac disease and gluten sensitivity. If the labs come back normal, many doctors dismiss gluten sensitivity all together. This leads to a lot of people going undiagnosed and staying sick.
There are Thousands of Different Types of GlutensPart of the problem with one of the serum lab tests (anti-gliadin antibody test) is that it is only sensitive for a very specific type of gluten called gliadin. Researchers have identified thousands of different types of gluten proteins found in grains, but lab tests don’t measure whether or not patients react to all of these different glutens – just gliadin. Serum lab test flaws don’t stop there. Most of these tests measure a specific type of antibody produced by your body’s immune system. The most common antibody types measured are IgA and IgG. Your body can make five different types of antibodies (see below).
- Immunoglobulin A (IgA)
- Tumor necrosis factor (TNF)