Research Review Shows That Gluten Causes Leaky Gut
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function.
Research Source:Physiol Rev. 2011 Jan;91(1):151-75.
Leaky Gut in Layman’s TermsI was recently interviewed by Leaky Gut expert, Karen Brimeyer. We discussed the ins and outs of this intestinal affliction in an easy to understand manner. You can watch the interview below: Karen specializes in helping people recover from leaky gut syndrome. You can learn more about her Leaky Gut Cure Program here <<< You can also read more on supplements to help correct the problem here <<<
Dr. Fasano Discovered Leaky GutMultiple research studies have linked gluten to the condition known as intestinal permeability – I recently had the privilege of speaking with one of the leading gluten sensitivity researchers in the world, Dr. Alessio Fasano. He is the head of research at the University of Maryland Celiac Research Center, and he is responsible for discovering the gluten/leaky gut connection. In this video, we discuss how this condition can affect the gut, the brain, and multiple other tissues in the body…
Making the Connection – The Gluten Free Warrior’s Stance:Most people assume that celiac disease and gluten sensitivity are the same thing. Fortunately, this archaic thought is rapidly changing as new research has proven that gluten sensitivity exists independently of celiac disease. Although it is well established that gluten often impacts the villi of the small intestine, it has also been shown to affect the body in multiple ways. These differences account for the massive failure of doctors to diagnose gluten sensitivity. Below is a diagram of environmental triggers to intestinal permeability (leaky gut). You will find that gluten sensitivity can directly and indirectly contribute to this problem. To the intelligent observer, this picture illustrates why simple antibody testing fails to accurately diagnosis gluten sensitivity. Antibody production is only one lab component of a multi-faceted problem. Click on image to enlarge…
How Does Gluten Play a Role in All of These Factors?
- Gluten – As stated above, gluten directly impacts the intestinal lining through zonulin production. Zonulin is a protein that directly causes leaky gut.
- Antibodies – Gluten contributes to the formation antibodies. Antibodies can cause the secretion of inflammatory chemicals leading to tissue damage. Additionally, through a process called molecular mimicry, antibodies can cross react with the tissues of the body causing autoimmune disease. Lab tests measuring these antibodies are typically not associated with gluten because most doctors are not trained adequately to identify the connection.
- Medications – Many medications commonly contain gluten leading to a direct effect. However, many chronic health conditions caused by gluten sensitivity are misdiagnosed leading to medicine prescriptions that are not only unnecessary, but can be detrimental to the gastrointestinal tract. Anti-acid medications are a common example. These medications predispose to infection and lead to abnormal bacteria presence in the gut. Over utilization of antibiotics to treat viral infection is another example.
- Stress – Although not a physical stressor, gluten is a chemical stressor on the body. Chemical stress comes in many forms. One of them is vitamin and mineral deficiency. Loss of key nutrients causes a fundamental breakdown in the body’s ability to modulate the healing and repair process.
- Bacteria – Gluten ingestion causes detrimental changes in intestinal flora (AKA gut dysbiosis) predisposing to infection. This is one of the reasons why so many yogurt companies are adding beneficial bacteria to their products. Gut dysbiosis is an epidemic in the U.S. If you need a gluten free probiotic go here <<<
- Cytokines – Gluten induces the production of pro-inflammatory cytokines (chemicals that damage cells).
- Neurotransmitters – Gluten causes neurochemical changes in the production of neurotransmitters (chemicals that allow the nervous system to communicate). Examples include: serotonin, dopamine, acetylcholine, epinephrine, and histamine. Gluten is also a neurotoxin that has been shown to damage nerve tissue. This is the reason so many with neurological disease (autism, migraine headaches, ADD, bipolar, schizophrenia, neuropathy, epilepsy, etc.) do well on a gluten free diet.
- Digestive chemicals – Gluten can damage the intestine, the pancreas, the liver, and the gall bladder. All of these organs play a pivotal role in the body’s ability to produce digestive chemicals and enzymes. When this mechanism is compromised, digestive processes start to break down and become ineffective.