Gluten Free Society Expert Interview Series
Dr. Seneff: Yes, I would love to see that. Another interesting thing that directly connects to glyphosate: Glyphosate kills bacteria, and it preferentially kills the good bacteria in your gut. One of those is bifido bacteria, and those guys are really important for processing the wheat, the gluten. When they’re destroyed by glyphosate, then the wheat suffers not being fully digested properly, such that it remains in the allergenic forms in your gut and causes this reaction. The fact that glyphosate kills these bacteria is another feature that’s going to lead to celiac disease.
Dr. Osborne: We have a function basically on the normal microbiome within the gut wall, that it has antibiotic-based effect on preferential bacteria that aid in the digestion of difficult to digest proteins. Have you seen the new research that’s come out on sourdough bread, adding high levels of lactobacillus?
Dr. Seneff: Yes, that’s another one, lactobacillus, that’s also preferentially killed by glyphosate. Glyphosate kills the ones that you need to be able to properly process these foods.
Dr. Osborne: We have an effect on gut bacteria. Then we have the fact that it makes food that is sprayed with the chemical more allergenic. In essence, people react or respond even more aggressively to them than they otherwise would. What are some of the other effects that glyphosate has on the human body, or on the plant, that affects the human as they eat it?
Dr. Seneff: That’s right, because the argument is that glyphosate disrupts this critical pathway in plants, called the shikimate pathway. That pathway produces three essential amino acids, which are called aromatic amino acids: tryptophan, tyrosine, and phenylalanine.
It turns out, these three amino acids are really important to our health and we depend on our food and our bacteria to produce them for us. The food that is exposed to glyphosate is depleted in these nutrients. The gut bacteria can’t produce them in the context of glyphosate, so we end up deficient in these nutrients, and one of the big ones is tryptophan.
Tryptophan is the sole precursor to serotonin, and serotonin deficiency is a huge problem in the modern world. It’s linked to depression, violent behavior, obesity, and celiac disease. I think serotonin deficiency is a critical piece of the puzzle, as well.
Dr. Osborne: No doubt. You said tyrosine, as well?
Dr. Seneff: Yes.
Dr. Osborne: We have tryptophan and tyrosine, so serotonin, as well as tyrosine being a precursor for thyroid hormone. I know in my clinic, that is one of the most prolific problems. Patients will come in and they will have hypothyroidism or will have developed Hashimoto’s disease.
Dr. Seneff: Right.
Dr. Osborne: What you’re saying about glyphosate is that it can cause deficiency in the actual amino acids in the food that we eat, because the plants need to be able to synthesize those foods to survive and glyphosate inhibits that process. What you’re also saying is that glyphosate destroys and damages our gut flora which helps us to digest the food and produce these amino acids, so there are two mechanisms of action here that are causing that deficiency?
Dr. Seneff: Yes. You’re good. Great summary.
Dr. Osborne: Big problems, right? I know one of the things in our clinic that we use or that we measure, oftentimes we’ll measure serotonin and oftentimes we’ll also try to measure thyroid hormone, and this is very prolific, we’ll see these numbers coming back. I know if we look at even the top five drugs in the United States, one of the top in that is antidepressants.
Dr. Seneff: Right.
Dr. Osborne: Now, let me hear your thoughts on serotonin’s impact on gut motility. We have a gut nervous system and its primary neurotransmitter is serotonin. Can you comment a little bit more on that?
Dr. Seneff: Well, yes. Actually, what I think happens, and this is speculation. We didn’t find papers that said this, but we could see the evidence from the details in the research–that the serotonin producers in association with celiac disease are very aggressive to make serotonin, whenever they have a chance. I think it’s because of the tryptophan deficiency.
As soon as you eat some food that has tryptophan in it, your cells in your gut that make serotonin grab the opportunity to make it, and they make too much, and then you get things like nausea and diarrhea. It gives you the gut mobility. It overdoes it. It’s because your body is so desperate for serotonin that the moment it gets the opportunity, it has to overdo it to take advantage of that opportunity, because it’s so scarce and it needs it so badly.
I think there’s sort of a swinging back and forth between too little and too much. It ends up with diarrhea and constipation, depending on the diet, because you just aren’t getting a steady supply.
Dr. Osborne: Great point. We get kind of a transient up and down effect based on what the diet is giving, because the gut is in a state of deficit.
Dr. Seneff: Oversensitivity because of the deficit.
Dr. Osborne: Right. Then it needs to be able to produce, so when it gets the opportunity it makes an abundance.
Dr. Seneff: Too much. Yes.
Dr. Osborne: One of the things I read about in your paper was the cytochrome P450, which is the enzymatic systems within the liver that help the body detoxify. Can you tell us the effect that glyphosate has on those particular systems?
Dr. Seneff: Yes. That is a huge piece of the puzzle, and were really astonished as we looked at how many different aspects of celiac disease were connected. Celiac disease is a very complex disease with a lot of interesting comorbidities. What’s amazing is that so many of them can be explained simply by the cytochrome P450 enzymes, which you can call CYP enzymes for short.
They’re amazing. There are so many of them in the liver, and they do so many different things, and all of the things that they do are disrupted in celiac disease. It’s really perfect. Glyphosate disrupts those enzymes, that’s been shown in rat liver. In the liver of a mammal, glyphosate interferes with the cytochrome P450 enzymes.
For example, a simple example, is that they activate vitamin D. When you measure vitamin D, you’re measuring the form that’s been activated by the liver using a CYP enzyme. I’m sure that you’ve been hearing, all of a sudden we have a massive vitamin D deficiency problem in this country, so the solution is just to pump everyone full of vitamin D supplements. The problem is due to, I believe, the fact that glyphosate is preventing the vitamin D from getting activated, which is why it’s low, and it’s low in association with celiac disease. It’s that simple.
Dr. Osborne: Okay. It actually inhibits the activation of vitamin D metabolites that go about to bring about hormonal functions for vitamin D.
To listen to the interview and get the in depth story from the source, click the link below.
Please share, like, tweet, etc. Spread the word and together we can increase awareness of this issue. You can read the transcript of the interview below.
Always looking out for you,
Dr. O – The Gluten Free Warrior
Think you might be gluten sensitive? >>> Take this short quiz for free <<<