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We were able to identify an intestinal Zot analogue, which we named zonulin. It is conceivable that the zonulins participate in the physiological regulation of intercellular tj not only in the small intestine, but also throughout a wide range of extraintestinal epithelia as well as the ubiquitous vascular endothelium, including the blood-brain barrier. Disregulation of this hypothetical zonulin model may contribute to disease states that involve disordered intercellular communication, including developmental and intestinal disorders, tissue inflammation, malignant transformation, and metastasis.
Most people (doctors included) connect gluten with intestinal symptoms and therefore, fail to understand the far reaching effects that gluten can have on different individuals. The discovery of the protein zonulin has identified yet another way that gluten can create problems for those ingesting it. It is thought that zonulin disrupts the epithelial barriers (such as found in the gut, brain, kidney, blood vessels, etc).
The disruption of the blood brain barrier could lead to a battery of different neurological and mental symptoms as this barrier is designed to keep toxic compounds out of the brain’s blood supply. We have already linked gluten induced damage to a multitude of neurological problems including:
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The entire contents of this website are based upon the opinions of Peter Osborne, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Peter Osborne and his community. Peter Osborne encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
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2 Responses
I have been diagnosed with Meniere’s Disease due to severe vertigo and now wonder if associated with my Celiac Disease ??? Any solutions or treatment ??? I do not cheat on my GF eating….