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Genetic Testing For Gluten Sensitivity is Being Recommended for IBS Sufferers

A review in the American Journal of Gastroenterology recommends that those suffering from irritable bowel syndrome (IBS) be genetically tested for gluten sensitivity intolerance. The Review elucidates the role of diet in the progression of IBS symptoms. The authors further state that the classic signs of celiac disease are often absent for those suffering with IBS even thought gluten is the culprit. IBS Gluten Testing Diagram Source: Am J Gastroenterl2009;104:1587-94.

Gluten Free Society’s Stance:

This article is a major breakthrough in the advancement for gluten sensitivity recognition. Traditionally IBS sufferers are told to “eat right and limit their stress”. IBS typically manifests as symptoms of gut pain, bloating, gas, and loose bowels. Endoscopic and other common diagnostic tests are most often negative leaving people without answers. Medical treatment of IBS is largely unsuccessful. Food intolerance and allergy and infections are the most common contributing factors in the development of irritable bowel symptoms. It is important to have a physician evaluate these areas. If you haven’t watched this video on gluten sensitivity, I highly recommend you do so now as gluten is a major cause of IBS. If you would like to be genetically tested for gluten sensitivity and your doctor won’t help you visit this link and you can get a home test kit sent to you.

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7 Responses

  1. Dr. Osborne, I assume they are looking for HLA-DQ2 and/or HLA-DQ8. You, however, include other genotypes in diagnosing susceptibilty to gluten sensitivity. What are those other genotypes, and what is the research that supports including those that you include?

    Reply

  2. Hello Dr. Osborne,
    I am also interested in the additional genotypes, research and what lab you recommend for testing.
    Thanks,
    Jeff Parisi

    Reply

    1. Jeff,
      If you can attend the Houston Gluten Free Expo on Feb. 4th, I will be going into this in great detail. Otherwise, you can join us for our next webinar on the topic. Call Xymogen supplement company and they can get you set up for the call.
      All the best,
      Dr. O

      Reply

  3. Hi,

    I have been off gluten for 3 months now. I suffered from IBS during my lifetime. These past two weeks I either had a stomach virus, or just having too much food that had a high acid content, but it was not nice.

    It’s been so long since something like this has happened to me.

    I am wondering, if I took a test, would anything show up as I have not had gluten for so long? I was told that you have to be actively eating wheat for it to show whether or not you have a sensitivity or not.

    Thanks!

    Reply

    1. Barbara,
      Genetic testing for gluten sensitivity is not skewed by your diet. The results are either positive or negative based on your genetics.
      Some testing looks at antibodies in your blood to determine a reaction to gluten. These tests are skewed by the diet. We do not perform these antibody blood tests.

      Reply

  4. Dr. Osborne,
    I don’t understand the Ttg AB neg (pos). Is that related to blood type??
    Thanks,
    Veronica Jessup

    Reply

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The entire contents of this website are based upon the opinions of Peter Osborne, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Peter Osborne and his community. Peter Osborne encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.

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