A new review in the American Journal of Gastroenterology recommends that those suffering from irritable bowel syndrome (IBS) be genetically tested for gluten sensitivity intolerance. The Review elucidates the role of diet in the progression of IBS symptoms. The authors further state that the classic signs of celiac disease are often absent for those suffering with IBS even thought gluten is the culprit.
Source: Am J Gastroenterl2009;104:1587-94.
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I am just wondering on this schematic what specific DQ genes would be considered “positive” vs. what would be considered “negative” (thereby ruling out gluten as a possible contributor)? I know traditionally most practitioners only consider DQ2 & 8 to be associated with typical celiac disease, but do not recognize the other gluten sensitivity genes.
Great point Jackie!
Only HLA- DQ2 and 8 are considered on this schematic. DQ1’s and 3’s are out of luck if they go the traditional route.