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More than 200 scientific studies have linked gluten sensitivity to liver disease.  In this review, the following liver conditions were linked to gluten intolerance:

  1. Reactive hepatitis ( coeliac hepatitis)
  2. Autoimmune liver disorders including – Autoimmune hepatitis, Autoimmune overlap syndrome,  Autoimmune (sclerosing) cholangitis, and Primary biliary cirrhosis
  3. Non alcoholic fatty liver disease
  4. Acute liver failure
  5. Cryptogenic cirrhosis
  6. Regenerative nodular hyperplasia
  7. Hepatocellular carcinoma (liver cancer)

a wide spectrum of liver injuries in children and adults may be related to CD and in particular: (1) a mild parenchymal damage characterised by absence of any clinical sign or symptom suggesting a chronic liver disease and by non-specific histological changes reversible on a gluten-free diet; (2) a chronic inflammatory liver injury of autoimmune mechanism, including autoimmune hepatitis, primary sclerosing cholangitis and primary biliary cirrhosis, that may lead to fibrosis and cirrhosis, generally unaffected by gluten withdrawal and necessitating an immunosuppressive treatment; (3) a severe liver failure potentially treatable by a gluten-free diet. Such different types of liver injuries may represent a spectrum of a same disorder where individual factors, such as genetic predisposition, precocity and duration of exposure to gluten may influence the reversibility of liver damage.”


Indian J Pediatr 2006; 73 (9) : 809-811.

Liver CirrhosisGluten Free Society’s Stance:

Liver disease can be fatal.  It has been well established that viral infection and alcohol can both damage the liver.  However; there are many who suffer with liver disease unrelated to either.  The cause for many of these conditions is unknown.

  • 500,000 gall bladder surgeries are performed in the U.S. annually.  Up to 40% of these surgeries have complications afterwards.
  • Non alcoholic fatty liver (NAFL) disease affects as many as 1/3 or U.S. adults.

The big question is why?  What is causing damage to the liver and gallbladder in so many individuals.  Is the answer surgery?  If gluten intolerance can cause all of the above conditions, shouldn’t we perform routine genetic screening for gluten sensitivity in those with liver disease of unknown origin before taking out their organs?

Now consider that liver disease can cause high cholesterol… Cholesterol medications can cause liver disease…Liver disease contributes to blood sugar abnormalities…contributes to fatigue…contributes to weight gain…contributes to fatty liver…

Gluten intolerance linked to liver disease

We can go on and on and on.  The point is, gluten intolerance can cause liver problems.  Most liver disease in the U.S. has no known cause.  It makes sense to investigate gluten as a causative factor.

Dr. Osborne – The Gluten Free Warrior

Dr. Peter Osborne
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7 responses on “Gluten Sensitivity and Liver Disease

  1. Social comments and analytics for this post…

    This post was mentioned on Twitter by sistersthreegf: Gluten Sensitivity and Liver Disease http://bit.ly/dwWcit

  2. […] A previous post on Gluten Free Society showed the connection between gluten induced liver disease (autoimmune hepatitis).  Now another new study points more autoimmune disease overlap in patients with autoimmune hepatitis. […]

  3. […] A previous post on Gluten Free Society showed the connection between gluten induced liver disease (autoimmune hepatitis).  Now another new study points more autoimmune disease overlap in patients with autoimmune hepatitis. […]

  4. eddie says:

    i have been gluten free for 18 months and started having chest pain on right side. it turned out to be fatty liver disease. how can this happen when gluten free if you say gluten is the cluprit? Also, my cholestrol has jumped over 40 points in the 18 months. I feel better off of wheat, but the lack of whole grains in my body are wreaking havoc on my body!

  5. […] Un post anterior sobre Gluten Free Society mostró la conexión entre inducida por el gluten enfermedad hepática (hepatitis autoinmune). Ahora, otro nuevo estudio señala más solapamiento enfermedad autoinmune en pacientes con hepatitis autoinmune. […]

  6. Kathy says:

    How long do you think it would take to see a change if you went gluten free after you found out you had a liver disease

  7. Brid says:

    I was diagnosed with pbc 11 years ago by a liver test. I never really had the symtoms of pbc. Lately I have become very senitive to gluten products. I cut out the gluten and I notice a big improvement. Now im wondering if I have pbc at all. Maybe im just gluten intolerent but im afraid to stop taking medication

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