
Researchers wanted to find out how many RAS patients had gluten sensitive enteropathy and assess whether or not a gluten free diet could improve the canker sores.
They found 247 patients with RAS and screened them with the IgA anti-endomysial antibody (EMA) test along with serum IgA and IgA anti tissue transglutaminase. Seven patients with at least one positive test then had duodenal biopsies and all were found to have gluten sensitive enteropathy. This explained why these 7 patients were not successfully treated with the usual anti-canker sore medications (topical corticosteroids, tetracycline, colchicines). Over the next six months, 4 of the patients that went on a strict gluten free diet improved greatly.
Researchers concluded that in patients with RAS, it’s appropriate to test for celiac disease, especially in those who don’t improve from a traditional prescriptions for RAS.
Source:
BMC Gastroenterol 2009; 9: 44. Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis.Gluten Free Society’s Stance:
It’s a little surprising that the researchers found that all 7 patients had a positive biopsy for gluten sensitivity enteropathy. Often this does not happen. A biopsy only selects a small amount of tissue, almost at random, and that tissue sample may not be reflective of what’s occurring in the intestinal tract. Everyone with gluten sensitivity won’t have a positive biopsy, and that could explain why the condition may not be identified.The researchers made a great correlation in this study, but there are still too many people that are suffering from undiagnosed gluten sensitivity enteropathy. The problem is finding them!
Dr. Kenneth Fine’s research has found that the most common symptom of gluten sensitivity is the canker sore. So the question becomes – Do you have chronic recurring canker sores and don’t know why? You may be gluten sensitive. Genetic testing might be a good idea…