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Leaky Gut and Autoimmune Disease

A recent paper published in the Annals of the New York Acedemy of Sciences connects intestinal permeability (AKA leaky gut syndrome) with the development of autoimmune diseases. The authors base their findings on what we know of celiac disease and Type I Diabetes. Both diseases share the same HLA-DQ genetics. As well, they both share the same environmental trigger – Gluten.


Ann N Y Acad Sci. 2009 May;1165:195-205.

Making the Connection – Gluten Free Society’s Stance:

Most people assume that celiac disease and gluten sensitivity are the same thing. This archaic thought is rapidly changing. Although it is well established that gluten often impacts the villi of the small intestine, it has been shown to affect the body in a variety of other ways. These differences account for the massive failure of doctors to diagnose gluten sensitivity. Below is a diagram of environmental triggers to intestinal permeability (leaky gut). You will find that gluten sensitivity can directly and indirectly contribute to this problem. To the keen observer, this diagram illustrates why simple antibody testing fails to accurately diagnosis gluten sensitivity. Antibody production is only one lab component of a multi-faceted problem. Click on image to enlarge…

How Does Gluten Play a Role in All of These Factors?

  1. Gluten – Gluten directly impacts intestinal integrity through zonulin production. Zonulin is a protein that causes directly causes leaky gut.
  2. Antibodies – Gluten contributes to antibody formation. Antibodies can cause the secretion of inflammatory chemicals leading to tissue damage. Additionally, through a process called molecular mimicry, antibodies can cross react with the tissues of the body causing autoimmune disease. Lab tests measuring these antibodies are typically not associated with gluten because most doctors are not trained adequately to identify the connection.
  3. Medications – Many medications commonly contain gluten leading to a direct effect. However, many chronic health conditions caused by gluten sensitivity are misdiagnosed leading to medicine prescriptions that are not only unnecessary, but can be detrimental to the gastrointestinal tract. Anti-acid medications are a common example. These medications predispose to infection and lead to abnormal bacteria presence in the gut. Over utilization of antibiotics to treat viral infection is another example.
  4. Stress – Although not a physical stressor, gluten is a chemical stressor on the body. Chemical stress comes in many forms. One of them is vitamin and mineral deficiency. Loss of key nutrients causes a fundamental breakdown in the body’s ability to modulate the healing and repair process.
  5. Bacteria – Gluten ingestion causes detrimental changes in intestinal flora (AKA gut dysbiosis) predisposing to infection. This is one of the reasons why so many yogurt companies are adding beneficial bacteria to their products. Gut dysbiosis is an epidemic in the U.S.
  6. Cytokines – Gluten induces the production of pro-inflammatory cytokines (chemicals that damage cells).
  7. Neurotransmitters – Gluten causes neurochemical changes in the production of neurotransmitters (chemicals that allow the nervous system to communicate). Examples include: serotonin, dopamine, acetylcholine, epinephrine, and histamine. Gluten is also a neurotoxin that has been shown to damage nerve tissue. This is the reason so many with neurological disease (autism, ADD, bipolar, schizophrenia, neuropathy, epilepsy, etc.) do well on a gluten free diet.
  8. Digestive chemicals – Gluten can damage the intestine, the pancreas, the liver, and the gall bladder. All of these organs play a pivotal role in the body’s ability to produce digestive chemicals and enzymes. When this mechanism is compromised, digestive processes start to break down and become ineffective.

Sum it all up –

Leaky gut contributes to autoimmune disease. The only known cause for any autoimmune disease is gluten sensitivity. We are blind fools to ignore this connection because it does not fit the status quo of the allopathic medical paradigm. If you have autoimmune disease and have not investigated gluten sensitivity as a contributing factor, you should. Learn more about genetic testing for gluten sensitivity now!

6 Responses

  1. Was diagnosed with MS after many, many years of strange symptoms. When the diagnosis finally came I had to choose… I take the drugs? I decided to wait and see and try some dietary changes. After much reading I decided to go gluten free. Well, this is the answer to my nearly life long problems. My MS symptoms are resolved and I feel wonderful! The only lasting issue is some numbness….lesions on the brain due the damage caused by years of gluten issues. Had my doctors recommended I go gluten free years ago I would have full feeling in all my extremeties. It’s hard not to hold a grudge, I mean these people who people worship should be able to give health and dietary advice not just write prescriptions. Well, now I know why I would always feel so much better when I would go on the Atkins diet!

  2. Great Post! So many people are dealing with LG and have no clue why they are sick and tired. Heal the gut, eliminate gluten and other toxins and you will start to heal.

  3. To Joni: please be careful with your MS!!! My sister was treated by an ND in Mass. for MS with dietary changes only and she is now in a nursing home with severe brain retardation. If she had taken the meds/injections prescribed by the MD’s AND the supplements/dietary changes prescribed by her ND, she would not be in the situation she is in now. I would hate to see this happen to anyone!!!! Listening closely to both sides of the medical spectrum and to your body are very important. You might feel better now, but those brain lesions can worsen. This is exactly what happened to my sister. Best of luck to you and All with MS.

  4. Dr. Fasano’s recent study on subjects with celiac and non celiac gluten sensitivity proved that those with NCGS don’t have leaky guts at all! In fact, he proved their guts have even less permeaibility than the control subjects without NCGS. I found his study to be very interesting! No damage, no anti self antibodies and no real evidence of any disease process seemes to add up to non celiac gluten sensitivity. For some reason…this just doesn’t add up to me! Or just maybe…it adds up to a 45 million dollar donation from someone who self diagnosed and then discovered she didn’t even have the genes to ever develop celiac disease!

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