Acute pericarditis (inflammation of the sack surrounding the heart) can be caused by virus or bacterial infection, but 85% of the cases have an unknown etiology (cause). The common presence of pro-inflammatory cytokines in the fluid around the heart and antinuclear antibodies (ANA – a blood marker commonly used to help diagnose lupus) in the serum as well as new autoimmune disease diagnosis lead the authors of this paper to suspect that peridarditis itself is caused by an autoimmune process.
Gluten Free Society’s Stance:
If acute pericarditis in the absence of infection is indeed an autoimmune process, then we should look to gluten as a potential progenitor as it is the only well known cause for autoimmune disease. There have been several associations between celiac disease and pericarditis in the medical literature to date. Some patients have had resolution of recurrent pericarditis on a gluten free diet.
Not all patients with gluten sensitivity will develop celiac disease. Many studies to date have shown that celiac disease is simply one of many autoimmune diseases caused by gluten exposure in those with HLA-DQ genetic susceptibility. Is acute pericarditis in the absence of celiac disease one of these gluten induced manifestations? Possibly yes.
If you suffer from recurring pericarditis and don’t know why, have your doctor perform HLA-DQ testing to rule out gluten sensitivity.