ALV003 is an orally administered mixture of two recombinant proteases engineered to degrade gluten into non-immunogenic peptide fragments, by targeting the glutamine and proline residues that are common in gluten. ALV003 consists of a glutamine specific cysteine protease (EP-B2) and a proline specific prolyl endopeptidase (PEP). ALV003 is being developed by Alvine as a potential treatment for patients with celiac disease.Enzyme therapy is definitely a novel idea for treating patients with gluten sensitivity. In my own practice, I use an enzyme formulation that helps break down gluten proteins to reduce the potential risk of damage caused by cross contamination or hidden dietary gluten. I don’t recommend using any enzyme formula as an excuse to eat gluten. Remember that even small amounts of gluten exposure can cause or perpetuate inflammatory damage in people with celiac disease of gluten sensitivities. However; using enzymes is definitely a positive approach in reducing the risk of damage.
new to the gluten free journey?