- Alpha Lipoic Acid
Alpha lipoic acid (ALA) is a potent, versatile antioxidant that is water- and fat-soluble. ALA has been shown to inhibit aldose reductase, which prevents sorbitol-induced leakage of important antioxidants from eye tissues and recharges ALA, vitamin C, E and glutathione. Recent studies have shown lipoic acid increases insulin-stimulated glucose disposal, both in the whole body and in skeletal muscle, thus helping to promote healthy blood sugar levels. ALA has also been shown to increase the GLUT4 pathway, a primary passageway for glucose to enter the cell and be used for metabolic energy.
- Ginkgo Biloba
Ginkgo Biloba extract is a well-studied botanical that increases cerebral blood flow and protects neurons from a variety of conditions and oxidant-induced damage.
- Carotenoids: Lutein, Zeaxanthin, Lycopene
Lutein and zeaxanthin are carotenoid pigments whose role in eye health is well-established from epidemiological, clinical and interventional studies. Lutein and zeaxanthin supplementation has been shown to protect the lens protein, lipid and DNA from oxidative damage and improves intracellular redox status when under oxidative stress. Increased dietary intake of carotenoids, especially lutein and zeaxanthin, protect the eye from oxidative stress.
A vital coenzyme for eye tissue, zinc is a necessary component in antioxidant enzymes including superoxide dismutase, glutathione peroxidase and catalase. Studies on monkeys with oxidative stressed retinas showed a 60% reduction in the activity of catalase and glutathione peroxidase as well as a 4-fold reduction in zinc concentration compared with controls. The enzymes responsible for digesting rod outer segments and preventing the build-up of lipofuscin, a lipid containing residue caused by normal “wear and tear” that can impair vision, are significantly less active in older individuals. These enzymes can be stimulated by adding zinc.
Bilberry extract contains a high amount of the antioxidants known as anthocyanidins, similar to those found in grape seeds. Bilberry has a long history of use in eye health. It has been shown to protect against an oxidative stress-induced immune response in the mouse uvea and to support night vision. The extract has also been found to support renewal and homeostasis of corneal cells.
A flavonoid found in a variety of herbs, vegetables and fruits, quercetin is a potent antioxidant which modulates pro-inflammatory pathways by inhibiting inducible ICAM1 expression. It has been shown to enhance epithelial barrier function in the intestines, to stabilize mast cells by releasing cytoprotective factors and to promote balanced proinflammatory mast cell mediators.
Taurine concentration is high in the retina and is required for retinal tissue growth. Researchers have suggested possible functions for taurine in the retina include protection of the photoreceptor, regulation of Ca2+ transport and regulation of signal transduction.
Does Not Contain: Gluten, yeast, artificial colors and flavors.
(as TRAACS Zinc Bisglycinate Chelate)
(Standardized to contain 25% Anthocyanidins)
(Powdered Ginkgo Extract)(Leaf)
(Standardized to contain 22% Flavonol Glycosides
and 5.4% Terpene Lactones)
How to use
Daily Use:2 capsules per day, or as recommended by your health care professional.
Optimal Use:3 capsules per day, or as recommended by your health care professional.
High Stress Use:4 capsules per day, or as recommended by your health care professional. `
How to Use:Take Capsules with at least 8oz of water. Contents may be removed from the capsule and taken by spoon immediately after mixing with a small amount of tepid water.
Yes, but supplementation in children should always be discussed with their pediatrician
If you are pregnant or nursing, consult your physician before taking this product.
Can be taken throughout the day, in divided doses if needed.
- Maitra I, Serbinova E, Tritschler HJ, Packer L. Stereospecific effects of R-lipoic acid on buthione sulfoximine-induced cataract formation in newborn rats. Biochem Biophys Res Commun 1996;
- Li Y, Liu YZ, Shi JM, Jia SB. Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes. Asian Pac J Trop Med. 2013 Jul;6(7):548-51.
- Lee,WJ, Song,KH, Koh,EH, Won,JC, Kim,HS, Park,HS, Kim, MS, Kim,SW, Lee,KU, Park,JY: Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun 332:885-891, 2005.
- Ahlemeyer B, Krieglstein J. Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci. 2003 Sep;60(9):1779-92.
- Ahlemeyer B, Krieglstein J. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer’s disease. Pharmacopsychiatry. 2003 Jun;36 Suppl
- Ponto LL, Schultz SK. Ginkgo biloba extract: review of CNS effects. Ann Clin Psychiatry. 2003 Jun;15(2):109-19.
- Abdel-Aal el-SM, Akhtar H, Zaheer K, Ali R. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients. 2013 Apr 9;5(4):1169-85.
- Koushan K, Rusovici R, Li W, Ferguson LR, Chalam KV. The role of lutein in eye-related disease. Nutrients. 2013 May 22;5(5):1823-39.
- Gao S, Qin T, Liu Z, Caceres MA, Ronchi CF, Chen CY, Yeum KJ, Taylor A, Blumberg JB, Liu Y, Shang F. Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells. Mol Vis. 2011;17:3180-90. Epub 2011 Dec 7.
- Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamin A, C and E and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA 1994; 272(18):1413-20.
- Nicolas MG, Fujiki K, Murayama K, et al. Studies on the mechanism of early onset macular degeneration in cynomolgus monkeys. II. Suppression of metallothionein synthesis in the retina in oxidative stress. Exp Eye Res 1996; 62(4):399-408.
- Cingle KA, Kalski RS, Bruner WE, et al. Age-related changes of glycosidases in human retinal pigment epithelium. Curr Eye Res 1996; 15(4):433-8.
- Wyszynski RE, Bruner WE, Cano DB, et al. A donor-age dependent change in the activity of alpha-mannosidase in human cultured RPE cells. Invest Ophthalmol Vis Sci 1989; 30(11):2341-7.
- Yao N, Lan F, He RR, Kurihara H. J Protective effects of bilberry ( Vaccinium myrtillus L.) extract against endotoxin induced uveitis in mice. Agric Food Chem. 2010 Apr 28;58(8):4731- 6.
- Canter PH, Ernst E. Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision–a systematic review of placebo-controlled trials. Surv Ophthalmol. 2004 JanFeb;49(1):38-50.
- Song J, Li Y, Ge J, Duan Y, Sze SC, Tong Y, Shaw PC, Ng TB, Tsui KC, Zhuo Y, Zhang KY. Protective effect of bilberry (Vaccinium myrtillus L.) extracts on cultured human corneal limbal epithelial cells (HCLEC). Phytother Res. 2010 Apr;24(4):520-4.
- Bito T, Roy S, Sen CK, et al. Flavonoids differentially regulate IFN gamma induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. FEBS Lett. 2002 Jun 5;520(1-3):145-52.
- Amasheh M, Schlichter S, Amasheh S, Mankertz J, Zeitz M, Fromm M, Schulzke JD. Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J
Nutr. 2008 Jun;138(6):1067-73.
- Penissi AB, Rudolph MI, Piezzi RS. Role of mast cells in gastrointestinal mucosal defense. Biocell. 2003
- Lombardini JB. Taurine: retinal function. Brain Res Brain Res Rev. 1991 May-Aug;16(2):151-69.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.