Folate, Vitamin B12, and vitamin B6 are essential B-vitamins that play a role in the metabolism of energy.

The three together play a major role in methylation processes, and help to metabolize a toxic compound called homocysteine.

A deficiency of vitamin B12, folate, and vitamin B6 can contribute to fatigue, depression, anemia, heart disease, neuropathy, slow healing, and a reduced ability to detoxify.

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