Home of Gluten-Free Society Forums All Gluten Free All The Time I am not understanding genetic tests and conclusions

This topic contains 5 replies, has 4 voices, and was last updated by Anne MacMillan Anne MacMillan 6 years, 5 months ago.

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  • #8309

    Confused
    I was genetically tested and found to have 4/4 alleles for gluten intolerance. Does this mean I have Celiac, or does Celiac refer to the damage that occurs? I am being told to never eat gluten again? Is that because I am celiac or because of ????

    #9917
    Norbert Banaszak jr
    redbird
    Member

    If your test is showing the HLA-DQ4,4 alleles you are being diagnosed with NonCeliac”Gluten Sensitivity” genetics. A person with the HLA-DQ2 or DQ8 alleles are diagnosed with Celiac Disease. If I understood what your test indicates then you don’t have Celiac Disease where your villi fingers in the intestines are being destroyed in an auto-immune response effort to remove the gluten. That is great, however, the only thing you can do to get healthy and stay that way is to go 100% Gluten/Grain/Soy free and don’t cheat. It is hard because there is hidden gluten in a lot of food/drink and even some foods/drinks can cause the false “similar protein” cross-reaction. There is data that shows that 10% of the proteins in coffee can falsely cause a gluten-type response in up to 90% of the folks with GS or CD. That is not gluten or the caffeine but tannin proteins that resemble the gluten proteins in structure!

    #9921

    I have had years of anemia inspite of getting plenty of iron in my diet. Doesn’t that point to a problem with the villi?

    #9922
    Norbert Banaszak jr
    redbird
    Member

    I have had years of vitamin deficiency too but I am attributing that to the diarrhea condition washing my vitamins and minerals out instead of being absorbed. Only the right tests from Enterolab or Cyrex,etc. can tell you if you have GS or CD and what deficiencies and cross-reactions and Dr. O can help you get the right testing and the right vitamins and supplements too. My research shows that it takes several years of totally getting over the gluten condition to start properly absorbing enough from our food again. That’s the reason for taking supplements until health is restored, however, most commonly available vitamins/minerals and supplements from the retail stores either use gluten for the white filler/binder or there is cross-contamination. We need the help but must be certain it is safe or it causes a lot more problems and continued bad health than the possibility of being helpful! Most of us are already very aware that gluten/grains/soy/legumes are our “root” problem and just need to keep chasing down the loose ends to get totally under control. Think about how far we’ve come since being totally sick all the time and work on the “little” things.

    #9929
    Theresa Vela
    Theresa
    Member

    Diana, did you have the testing done through Dr. Osborne’s office? If so you can call and speak to a genetics counselor at the lab he used for the testing. (Kimball Genetics 1-800-320-1807). I recently also tested positive for 4 alleles and they were very helpful when I called them. Don’t know if they can help if your test was done elsewhere but might be worth a try.

    #10301

    @redbird said:
    If your test is showing the HLA-DQ4,4 alleles you are being diagnosed with NonCeliac”Gluten Sensitivity” genetics. A person with the HLA-DQ2 or DQ8 alleles are diagnosed with Celiac Disease. If I understood what your test indicates then you don’t have Celiac Disease where your villi fingers in the intestines are being destroyed in an auto-immune response effort to remove the gluten. That is great, however, the only thing you can do to get healthy and stay that way is to go 100% Gluten/Grain/Soy free and don’t cheat. It is hard because there is hidden gluten in a lot of food/drink and even some foods/drinks can cause the false “similar protein” cross-reaction. There is data that shows that 10% of the proteins in coffee can falsely cause a gluten-type response in up to 90% of the folks with GS or CD. That is not gluten or the caffeine but tannin proteins that resemble the gluten proteins in structure!

    Hi Redbird, I have just had my results back from Dr. Osborne and I tested positive for the HLA-DQ8 alleles. I was told that this does NOT mean that I have Celiac disease but shows that there is a very strong likely hood that I will develop it if I do not go gluten free. Just wanted to help clarify that point.

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