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Ultra Immune IgG Powder

(19 customer reviews)

$59.95 or subscribe and save 10%


UltraImmune IgG

Immunoglobulin Concentrate From Colostral Whey Peptides

Suggested Use

Mix one tablespoon (about 5g) into 2-4 oz of water and consume daily, or take as directed by your healthcare practitioner.


Wheat, gluten, yeast, soy, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Clinical Applications

Supports Immune Function by Providing Immunoglobulins and Other Immune Factors*

Supports the Body’s Normal Gut Repair Pathways*

Helps Maintain a Healthy Microbial and Cytokine Balance in the Gut*

Promotes Overall Health and Well-Being*

UltraImmune IgG is an immunoglobulin concentrate derived from colostral whey peptides. It delivers natural immunoglobulins (standardized to a minimum of 40% IgG), bioactive proteins, and growth factors. These components support immune function, healthy cytokine activity, gut barrier function, and gastrointestinal health and tissue repair. Advanced coagulation and filtration techniques make UltraImmune IgG a unique, GRAS formula that is superior in its bioactive composition and its purity.*


Beyond Colostrum: Immunoglobulin Concentrate from Colostral Whey Peptides

UltraImmune IgG is the result of advanced coagulation and filtration technologies that separate bioactive substances and then concentrate them. These precise systems produce a potent, pure, and generally recognized as safe (GRAS) immunoglobulin concentrate from colostral whey peptides. UltraImmune IgG provides immunoglobulins, including a minimum of 40% IgG; bioactive and growth factors; oligosaccharides; and gangliosides. Each of these components provides the user with different and complementary health benefits.1


Oral consumption of immunoglobulins derived from colostrum is a means of supporting passive immunity.[2-5] Immunoglobulins flag antigens for the immune system. In doing so, immunoglobulins become key participants in protecting the body and eliminating unwanted molecules. UltraImmune IgG delivers immunoglobulins and is particularly high (minimum of 40%) in IgG. Among immunoglobulins, IgG is said to be the most versatile, carrying out all of the functions of immunoglobulin molecules.*

Bioactive and Growth Factors

Sialic acid is an essential component of mucins, glycoproteins, oligosaccharides, and gangliosides and is therefore important to the function of cell membranes and membrane receptors. It is also important for normal brain development. Sialic acid containing oligosaccharides in bovine colostrum can prevent certain antigens from binding to host tissues. Lactoferrin is an immune-supporting, iron-binding glycoprotein naturally found in bovine colostrum. It plays an important role in immune regulation and in the body’s defense mechanisms.[6] Studies suggest that growth factors from bovine colostrum, including IGF-1 (insulin-like growth factor) and TGF (transforming growth factor), stimulate cell growth in the gut to strengthen the gut lining, help build lean muscle mass, and slow protein catabolism.[1] Furthermore, improvements observed in exercise performance by athletes taking colostrum have been attributed to growth factors.*

Proline-Rich Peptides

Proline-rich peptides (PRPs), which were first isolated from ovine colostrum and later from bovine colostrum, are intercellular signaling molecules. They act as regulatory Clinical Applications substances that have the unique ability to modulate and stabilize various biologic processes in the body, such as cytokine and immune processes.[1] The in vitro and in vivo effects of PRPs on immunoregulation, including their effects on the maturation and differentiation of thymocytes and humoral and cellular immune responses, have been demonstrated. Also of great interest are the many studies suggesting their beneficial effects on age-associated changes in neurological health.[7] For instance, in vivo work revealed that PRPs alleviate beta-amyloid cytotoxicity in hippocampal neuronal cells; in humans, PRPs provided an early beneficial effect on cognitive symptoms and daily functioning at a dose as low as 100 mcg/d every other day.[8,9] Five grams of powder or eight capsules of UltraImmune IgG provides 1% to 2% (50 to 100 mg) PRPs.*


Bovine milk oligosaccharides, which are a component of lactose, are modulators of gut microbiota. They provide protection by acting as decoys to attract antigens and inhibit them from binding to epithelial surfaces of the intestine.[10] Evidence also suggests that oligosaccharides act as growth promoters for a selected class of beneficial bacteria[11] and contribute to the development and maturation of the intestinal immune response.[12] Approximately 66 acidic and neutral oligosaccharides, including sialyloligosaccharides, which are known for their high biological activity in humans, have been detected in IgG concentrate from colostral whey peptides.*[13]


Gangliosides are vital to the structure and function of cell membranes. They support neural development, and they have roles in supporting gut integrity, influencing immune cell signaling, modulating cytokine activity and production, and affecting the adherence and toxin production of antigens.[14-17] Research has demonstrated that providing gangliosides in the diet increases ganglioside content in the intestinal mucosa. Studies have indicated that low levels of gangliosides in the intestinal mucosa are associated with increased levels of cytokines, susceptibility to antigens, and poor gut integrity.[14] The ganglioside composition of bovine milk is predominately GM3 and GD3.*[15]

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.


  1. Godhia M, et al. Curr Res Nutr Food Sci. 2013;1(1):37-47. http://dx.doi. org/10.12944/CRNFSJ.1.1.04
  2. Hurley D. [Dissertation]. Brookings, SD: South Dakota State University; 1994.
  3. Hurley WL, et al. Nutrients. 2011 Apr;3(4):442-74. [PMID: 22254105]
  4. Rump JA, et al. Clin Investig. 1992 Jul;70(7):588-94. [PMID: 1392428]
  5. Schaller JP, et al. J Infect Dis. 1992 Apr;165(4):623-30. [PMID: 1313067]
  6. Berlutti F, et al. Molecules. 2011 Aug 16;16(8):6992-7018. [PMID: 21847071]
  7. Janusz M, et al. Cell Mol Biol (Noisy-le-grand). 2013 Nov 3;59(1):4-11. [PMID: 24200016]
  8. Froud KE, et al. J Alzheimers Dis. 2010;20(2):423-26. [PMID: 20164569]
  9. Bilikiewicz A, et al. J Alzheimers Dis. 2004 Feb;6(1):17-26. [PMID: 15004324]
  10. Lane JA, et al. Int J Food Microbiol. 2012 Jul 2;157(2):182-8. [PMID: 22647676]
  11. Aldredge DL, et al. Glycobiology. 2013 Jun;23(6):664-76. [PMID: 23436288]
  12. Lane JA, et al. Br J Nutr. 2013 Dec;110(12):2127-37. [PMID: 23710626]
  13. Barile D. Milk oligosaccharides. Confidential Report. Brookings, SD: Sterling Technology; 2011. [on file]
  14. Miklavcic JJ, et al. J Nutr Metab. 2012;2012:280286. [PMID: 22506104]
  15. Lee H, et al. J Agric Food Chem. 2013 Oct 9;61(40):9689-96. [PMID: 24024650]
  16. Sánchez-Juanes F, et al. Biol Chem. 2009 Jan;390(1):31-40. [PMID: 18937626]
  17. Park EJ, et al. J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):321-28. [PMID: 20118807]



19 reviews for Ultra Immune IgG Powder

  1. .

    Best colostrum supplement I have ever used. Gut symptoms gone after a week of using this twice a day.

  2. .

    My kids love this stuff. They actually ask me to make them shakes with it every morning.

  3. Diana T.

    How many servings should be had daily, only one?

  4. .

    I sent a question on the other igg powder in the purple container. How does this compare to the other. I am gluten free with most all products not just food and dairy free although not sure if that’s a real sensivity. Having CVID as I explained in first question and low IGG sand IGA. Would this be ofnbetter benefit than the other as it has more IGG and perhaps I can stop my HYQUIVIA infusions. I need something because I just don’t want anyone else’s blood products frankly. Please help me and direct me to research on this so I can discuss with my primary dr. Not my immunologist.

  5. Pam M.

    Great produce to boost my immune system during the winter and flu season.

  6. Carolyn T.

    I am just finishing my first container. Taste is ok and mixes well with water or almond milk. I think it has helped my digestive issues some but would have to purchase more than one time to really know results. I do find it expensive for no more servings in the container I need to use it twice a day.

  7. Carolyn T.

    I finished one container of the Ultra Immune IgG Powder. the taste is ok and mixes well with almond milk. I think it has helped some but will take more than one container for good results.

  8. Kimberely B.

    Just started using this in my smoothies. I have not had any bad reactions like I would normally to milk.

  9. Priscilla C.

    I was bitten by a spider with a rare bacteria on it’s mouth. My immune serums IgA,M, and G are in the lower 1/3 of the range. I added Dr.Osborne’s UltraImmune IgG and was able to get off the 3rd Gen antibiotics and, in fact, all antibiotics by using an N.D. proprietary product and the IgG. The IgG is helping to whack the thing as well as 2-antibiotics, and gained so much energy!

  10. Priscilla C.

    Excellent product!
    A retention of 40% antibodies. Other colostrum products are 22% and lower.
    My natural antibodies are in the lower 1/4 to 1/3 range. I feel so, so much better taking this product.

  11. .

    I am just about finished with my first container of Immune IgG powder and I purchase this to help with my long term constipation issues and poor digestive health. What would be incredibly helpful would be a protocol of instructions to take ALL supplements and vitamins…. finding a functional Medicine doctor to help with this has been extremely challenging. The few functional Medicine doctors in our area want me to “buy in” to their program at a very expensive rate…. I am following the “ No Grain, No Pain” book and now about 18 weeks into it ….my entire health has improved significantly.All my asthma symptoms resolved between weeks 5 and 6, My platelets have gone from 550 down to 475. Not sure that this product alone is the answer…: the process takes time. Many thanks Dr O for giving me my life back.

  12. Andy W.

    Dr Osborne, Would this product contain any casein ? Thank you andy

  13. Patricia H.

    I have been following Dr. Osborne for quite some time. He has given me keys to unlocking health issues. I listen to his videos, his talks, read No Grain No Pain, even when I think I have heard it before because I always get a new angle or learn something. Healing is also a mindset; you have to put forth effort as no one can do it for you. I actually ordered this product by mistake because I use the other powder (Immune Shield). I had been out for about a week and when I started on this powder, the changes I saw were amazing. I had never really noticed what some of these products do for me but knew I needed them for healing. I love the products on this site. I use many. There is no bad taste after these products, though the protein powder I can only do 1 scoop as a serving. I don’t usually leave reviews, however I really needed to give my thanks for all that Dr. Osborne is doing in bringing us closer to healing.

  14. .

    Great product

  15. Kristi C.

    My functional doctor recommended I take IgG powder to help heal my gut. I compared several brands, ingredients and potencies and then bought this one. I like the clean ingredients and it was less expensive than some others when comparing dosage amounts. It is easy to take and I feel I have less fatigue lately.

  16. Bill N.

    Best product for the money that I found works as good as enteragam but costs a lot less!

  17. Tatsushi F.

    The product appears to help maintain equilibrium of emotion.

  18. Linda M.

    Ultra immune IgG powder. My functional medicine doctor started me on her own product for Digestive issues. Then I found Dr Osborn about a year ago I switched to his product which is exactly the same and Cost Less. It mixes easily in a little water. I also take the ultra Digest for the few times I eat out. It seems to help with gluten and Dairy. When I had questions about subscription the staff got right back to me. Dr Osborne and your staff thank you, Linda

  19. Dena M.

    I believe in this product. I don’t understand why it does not mix for me when other reviews state it mixes well.

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