new to the gluten free journey?


Hist Assist

(52 customer reviews)

$40.95 or subscribe and save 10%


Hist Assist is designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. Our formula includes quercetin, a powerful flavonoid, to support healthy histamine levels. Bromelain enhances the absorption of quercetin and supports mucosal tissue health. Stinging nettles leaf balance hyper-immune response and N-acetyl cysteine clear the airways by promoting normal viscosity of mucus. This powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation.

  • Supports Immune Balance in Hypersensitive Individuals
  • Supports Sinus and Respiratory Health
  • Promotes Normal Viscosity of Mucus
  • Clears Nasal Passages

Key Ingredients Include: 

  • Vitamin C – has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.
  • Quercetin Dihydrate – biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea; Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds.
  • Stinging Nettle (leaves) – Urtica dioica, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages; it controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response.
  • Bromelain (from pineapple) – proteolytic enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin; shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.
  • N-Acetyl-L-Cysteine – (NAC) helps reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.

Does Not Contain: Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

52 reviews for Hist Assist

  1. .

    I had really hoped this product would help me with a horrible cough I get this time of year. I usually take Zyrtec to fight it off, but I would much rather use something natural. I took it as directed 3 times a day for 1 week and saw little to no results with the cough. I understand it really works well for some people. Sadly I was not one of them. I had to stop taking it after 1 week due to the bowel distress I started having. I think it irritated my system. I would send it back for a refund if I could, but they don’t take back open products. If you try it, I wish you the best, but it didn’t work for me.

  2. .

    Love this product! Worked great for my seasonal allergies.

  3. Celia W.

    Great product, it really did the job for my runny, itchy eyes and nose.

  4. Audrey W.

    We find it very helpful for treating our allergies!

  5. daniel w.

    so far this product has worked very well

  6. Denise B.

    Very easy to digest. This is my second order!

  7. .

    I’ve been taking this for two months. I replaced a RX for Ketotifen that had to be compounded monthly, with this product . I had also taken plain quercetin in the past with poor results. I live with MCAS.

  8. Sharon N.

    Just two of these guys before bed help my itchy skin! Thanks

  9. Geir A.

    I bought this product for my daughter, she has taken alergi medisin for many years. I told here to try the Hist Assist.
    After 2-3 weeks she was so much better, she would never thought that was possible. No more medisin!
    Great produkt!

  10. .

    I always deal with pesky spring allergy symptoms, but this spring I didn’t want to have them acting up with the COVID19 pandemic danger. Hist Assist has prevented the rhinitis that happens every year along with inflamed eyes and itchy throat and ears. I feel just a little safer in that my nasal passages won’t be all hot and bothered as I stay indoors to help flatten the curve of the virus.

  11. Susan B.

    I used to wake up in the morning with a literal mountain of Kleenex next to my pillow. Now, I take 2 caps before bed and only need 1 or 2 tissues before the morning.

  12. Debra F.

    While suffering from terrible allergies this year, I decided to give Hist Assist a try. I sure am glad I did as it definitely worked! So nice to have a safe, natural solution that works this well for allergies.

  13. Chuen T.

    I have been taking this for about a month. Lately the pollen count is high. Every year during this time, I’m usually miserable. I would sneeze 4 or 5 times in a row and several times a day. I would have red watery eyes. A couple days ago, I only sneezed twice. And I didn’t sneeze any today. A little while ago when it was on sale I bought three more bottles.

  14. Tiffany F.

    Better than Zyrtec!!

  15. Mary B.

    This is the first time I have ever tried this product. I was very impressed with it it took care of my itchy eyes and running nose. My bf also got some relief from his allergies.

  16. Peter U.

    great product! see a positive change

  17. Susan D.

    I haven’t used this on a regular basis yet, but I have taken it on occasions when I’ve eaten food that has triggered congestion, and the congestion went away. Worked as I had hoped!

  18. Fred G.

    I just recently started taking these products. Great results so far. Have not been diagnosed with allergies but have sinus issues typically early morning. Dr. Prescribed Fluticasone Propionate which I used once until I researched the side effects. Hist Assist & Ultra NAC have provided excellent results from day one.

  19. Kulie F.

    As I have MCAS (Mast Cell Activation Syndrome) as well as histamine intolerance, I struggle with a variety of symptoms ever since I was little (I couldn’t jog outside in cold weather because cold temp would trigger MCAS and I’d be covered in hives, can’t smell perfume because that will not only make me feel nauseated but also instantly make my skin itchy, etc.). Even though I’ve learned how to cope with this over the years, there are times when I just can’t handle the amount of histamines in my system due to chronic stress (emotional and physical). I’ve had 3 major anaphylactic shocks and almost died… For this reason, I had to carry Epipen at all times. This product literally saved my life! It’s been a month since I started taking it 3 times a day and I can feel the difference because I don’t get hives as often as I used to. And I can sleep better because I have less histamine in my system. I’ve tried many other similar products but this is by far the best one, at least for me for sure! Thank you, Dr. Osborne! I can’t thank you enough!!

  20. .

    This product worked for me, I had relief without any stomach upset or side affects.

  21. Barbara A.

    I have had a problem with hives for over 3 years and have used many allergy drugs. The Hist Assist has calmed them down and am so much less itchy and not having to take allergy drugs. I also sleep better because I’m not having intense itching at night. Thank you thank you, thank you.

  22. Barb W.

    just stated it, but I am happy there is something natural to use instead of drugs.

  23. Deborah S.

    I use this in conjunction with another allergy asthma med at bedtime and an Advair inhaler.
    Just today, the breezes coming thru the window were generating sneezes & congestion.
    Took Hist Assist & went outdoors an hour later with NO allergy symptoms!
    Thank you!

  24. .

    Works like magic

  25. Debbie H.

    My husband constantly blew his nose, cleared his throat and more and so I had him try this as nothing else worked and we avoid OTC’s He was skeptical, but said he was noticing a difference so I bought more and it’s helping! He’s a histamine factory!

  26. .

    Have not noticed any improvement in sinus/respiratory issues.

  27. Lezlie J.

    After dealing with allergies for over a month once the harvest began, I could not get them controlled even with allergy medications. Within 24 hours of taking hist assist as directed my allergies were non-existent and haven’t flared up since.

  28. .

    Great for allergy issues

  29. .

    I love this formula. I have side effects with the over the counter and prescribed drug options. Not with Hist Assist. So happy to find this product.

  30. .

    This has been a life saver for me, I use it when I have sinus problems and headaches. No longer have to take over the counter products and love that it is gluten free.

  31. Patricia W.

    I have such a hard time with Mast Cell Activation Syndrome, and histamine reactions.
    Some get pretty serious, and I’ve ended up in the ER twice with severe anaphalaxis. The ER Dr told me at my last visit that I had already started to die. He warned me that anything I put in my body could kill me. Hist Assist has helped me so many times in calming down, or preventing a histamine reaction, and it works fast. Usually my symptoms will go away within 10-15 minutes. Can’t say enough good about it. I am so thankful for Hist Assist.

  32. .

    This product is great for my histamine issues with mcas, and it is the best price that I have found for the quality.

  33. Peter U.

    Helps me with my allerhies!
    Almost 200% relief ehen pollen hits me!
    Three cheers

  34. Ali K.

    I took the hist assist and stopped sneezing almost right away!

  35. Lindsey M.

    This time of year now days the pollen or whatever hits me hard. My sinuses get super inflamed. I was constantly irrigating my nose, but the relief was limited. So glad I found this product. It helps considerably, although when I tried the loading dose, it did a number on my bowels.

  36. .

    I use this product to help with my mcas. I feel like it helps keep my symptoms at bay.

  37. Gail M.

    Hist Assist has really helped my seasonal allergies calm down a great deal. I’m on my second bottle. Have not had any side effects and have not had to take sinus meds this spring.

  38. Kayleigh K.

    Found Dr Osborne’s gluten free society on a middle of the night prayer & holy grail! I’m so grateful for his pursuit of truth and education for all. Hist Assist is my game changer. I’m also 2 months into eating gluten & dairy free, low-histamine, & exploring my FODMAP triggers. Also was able to stop! daily flonase & Zyrtec (a task I had failed at several times times prior) thanks to Hist Assist & ultra sinus support. Grateful to have also found his post about histamine intolerance because I check just about all the boxes. Likely owing to the fact that daily use of antihistamines for 16 years. Shaking my head. Don’t get me started on the failed wealthcare system in this country. I’ve seen several doctors in 2 states and they’ve told me to take antihistamines. Because of Dr Osborne, I now know histamine is a) an important neurotransmitter & b) suppressing it is not the way! I’m empowered.

  39. Elizabeth C.

    With ragweed in full bloom, I depend on Hist Assist even more! Thank you so much.

  40. Dahne R.

    Host-Assist is excellent! My husband suffers from allergies and asma. His doctor told him that he’s allergic to the planet. Well I ordered Hist-Assist to see if it would help him stay away from all the steroids that he needed and it worked at relieving his symptoms. He is breathing much easier without the drugs. I use it also for food allergies. It doesn’t get rid of them but if I ingest something and I breakout, I feel better fast. It stops congestion. Thank you Dr Osborne!

  41. Catherine W.

    I have been taking Hist-Assist for several years now. It doesn’t get rid of all symptoms, but it is better than anything else I have ever tried. My symptoms are nothing like they used to be. I am a life king user.

  42. Chris B.

    This is one supplement that my husband will not go without. It keeps his sinus issues at bay.

  43. Ann-Marie M.

    I am using this with each meal to combat histamine release. I have just started using this, but I feel that it is making a difference and keeping symptoms down. I really like how this product contains multiple ingredients to combat histamine.

  44. Karen G.

    Hist Assist is my go to for seasonal allergies, absolutely essential for me. I have been using this product for years and will never go without it.

  45. Lily S.

    Many many Thanks to Dr. Osborne’s great invention Hist Assit! My husband and I have been talking it for years for our allergies. It helped tremendously. We haven’t taken any allergy medicine for years. We feel healthier and happier since we found Dr. Osborne’s supplements. Thank you Dr. Osborne!

  46. Tanya C.

    Great supplements, helping with my seasonal allergies! Thank you Dr. Osborne!

  47. Quieta B.

    This is the best product for histamine that I have ever used and several family members are using it also
    Impatiently waiting for the kidsversion to come back in stock

  48. .

    It has helped a lot to clear up that feeling of allergy that seems to linger around this time of year

  49. .

    Excellent product for my allergies. Love that they contain natural ingredients.

  50. Brandy R.

    This product has been great for my son and helping him with his allergies.

  51. Astrid C.

    This product is incredible for me. Previously, I was unable to go outdoors when my husband was mowing the lawn due to significant environmental allergies. This summer, I have to help with weed eating as my husband now has bad knees. This product helps me do it! I take two tablets before I start, and another tablet after I finish. Although I get slightly stuffy, my allergies remain under control. What a blessing to find a natural product instead of using the antihistamine I was on for over 20 years!

  52. Fred G.

    I see a review from me 4 years ago. Which is about the time I started using Hist Assist. The synergistic formula of this product has and continues produces great results for me and my family. Without the load dosing.

Add a review

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Sing up to our newsletter for 10% off your first order!

Receive the latest strain releases, exclusive offers and 10% OFF welcome discount.