Hist Assist

Nasal, Sinus, and Immune Support for Seasonal Changes


Hist Assist

Nasal, Sinus, and Immune Support for Seasonal Changes


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A targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals

Hist Assist is designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. Our formula includes quercetin, a powerful flavonoid, to support healthy histamine levels. Bromelain enhances the absorption of quercetin and supports mucosal tissue health. Stinging nettles leaf balance hyper-immune response and N-acetyl cysteine clear the airways by promoting normal viscosity of mucus. This powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation.


  • Supports Immune Balance in Hypersensitive Individuals
  • Supports Sinus and Respiratory Health
  • Promotes Normal Viscosity of Mucus
  • Clears Nasal Passages


  • Vitamin C – has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.
  • Quercetin Dihydrate – biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea; Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds.
  • Stinging Nettle (leaves) – Urtica dioica, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages; it controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response.
  • Bromelain (from pineapple) – proteolytic enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin; shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.
  • N-Acetyl-L-Cysteine – (NAC) helps reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.

Does Not Contain: Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 60

Amount Per Serving
%Daily Value

Vitamin C
(as Ascorbic Acid USP))
300 mg
Quercetin Dihydrate
400 mg
Stinging Nettle (Leaves)
400 mg
Bromelain (2,400 GDU/g)
(from Pineapple)
100 mg
N-Acetyl-L-Cysteine USP
50 mg

Other Ingredients: Natural Vegetable Capsules, Magnesium Stearate, Silicon Dioxide, and Stearic Acid.

How to use

Daily Use:

Take two (2) capsules per day

Optimal Use:

Take four (4) capsules per day, in divided doses

High Stress Use:

Take (6) capsules per day, in divided doses

How to Use:

Capsules can be taken with or without food. Contents may be removed from the capsule and taken by spoon immediately after mixing with a small amount of tepid water.


Is this safe for children?

Safe over the age of 12, supplementation in children should be monitored by their pediatrician.

Is this safe for a pregnant or nursing mother?

Yes, but pregnant or nursing mothers should always consult with their health professional before supplementing.

Should this be taken at a specific time of the day?

Can be taken at any time of the day

The Science

  1. Della Loggia R, Ragazzi E, Tubaro A, et al. Anti-inflammatory activity of benzopyrones that are inhibitors of cyco- and lipo-oxygenase. Pharmacol Res Commun 1988;20:91-94.
  2. Kim HP, Mani I, Iversen L, Ziboh VA. Effects of naturally-occurring flavonoids and bioflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea pigs. Prostaglandins Leukot Essent Fatty Acids 1998; 58:17-24.
  3. Otsuka H, Inaba M, Fujikura T, Kunitomo M. Histochemical and functional characteristics of metachromatic cells in the nasal epithelium in allergic rhinitis: studies of nasal scrapings and their dispersed cells. J Allergy Clin Immunol 1995;96(4):528-36.
  4. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990; 56:44-47.
  5. Obertreis, B. et al. Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid. Arzneimittelforschung 1996; 46(1): 52-56.
  6. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999; 54(6): 960-3.
  7. Cichoke AJ. The Complete Book of Enzyme Therapy.(1999). Garden City Park, NY: Avery Publishing Group.
  8. Yim CY, et al. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immul 1994;152:5796-5805.
  9. Ziment, I. Acetylcysteine: a drug that is much more than a mucokinetic. Biomed Pharmacother 1988; 42(8):513-519.
  10. Millar, A.B. et.al. Effect of oral N-Acetyl Cysteine on mucus clearing. Br J Dis Chest 1985; 79: 262-266.
  11. Bland JS, Costarella L, Levin B, et al. Clinical Nutrition: A Functional Approach. Second Edition. (2004). Gig Harbor, WA: Institute of Functional Medicine.
  12. Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem 1996;25:189-213.

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