I’ve been going through the same thing. Some supplements make me feel worse right away, and some later. It’s hard to know which ones are the culprits if you take a lot of them each day. I also have a cabinet full of supplements, and 2 bags of ones I can’t use anymore in my garage. What a waste. I do know one thing for sure, “Trial and error” can mean lots of unnecessary suffering. Better to go to a well trained professional and have him tell you what your body needs, and then get them from a good reputable source, like Dr. O’s site.